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. 2017 Jan 11;17:6. doi: 10.1186/s12874-016-0284-2

Table 1.

Simulation results for the high accuracy scenario

Random-effects ρ η¯ ξ¯ ση2 σξ2 ρ Failure
distribution bias (s.e.) bias (s.e.) bias (s.e.) bias (s.e.) bias (s.e.) rate %
Normal-Normal
Normal 0.2 -0.19 (0.33) 0.06 (0.23) -0.47 (0.46) -0.13 (0.23) -0.04 (0.27) 2.5
0.6 -0.16 (0.33) 0.03 (0.23) -0.42 (0.47) -0.12 (0.23) -0.15 (0.22) 1.8
0.8 -0.17 (0.34) 0.02 (0.23) -0.38 (0.48) -0.10 (0.24) -0.19 (0.18) 1.8
Binomial-Normal
0.2 0.02 (0.37) -0.01 (0.24) -0.10 (0.67) -0.03 (0.28) 0.02 (0.36) 6.2
0.6 0.02 (0.38) -0.01 (0.24) -0.03 (0.71) -0.02 (0.28) -0.01 (0.28) 11.1
0.8 0.01 (0.37) -0.00 (0.24) -0.03 (0.69) -0.01 (0.29) -0.02 (0.20) 19.5
SIMEX
0.2 0.08 (0.35) -0.07 (0.25) 0.05 (0.59) 0.14 (0.30) -0.03 (0.28) 0.0
0.6 0.08 (0.35) -0.07 (0.25) 0.08 (0.59) 0.13 (0.29) -0.13 (0.23) 0.0
0.8 0.05 (0.35) -0.06 (0.25) 0.07 (0.59) 0.14 (0.30) -0.18 (0.19) 0.0
Normal-Normal
t 0.2 -0.22 (0.39) 0.09 (0.28) 0.07 (0.72) 0.16 (0.38) -0.06 (0.26) 1.6
0.6 -0.23 (0.41) 0.04 (0.28) 0.23 (0.80) 0.18 (0.38) -0.13 (0.22) 0.7
0.8 -0.20 (0.41) 0.03 (0.29) 0.21 (0.78) 0.22 (0.41) -0.17 (0.17) 0.8
Binomial-Normal
0.2 0.02 (0.46) 0.01 (0.30) 0.74 (1.13) 0.34 (0.47) -0.01 (0.33) 3.6
0.6 -0.02 (0.48) -0.01 (0.30) 0.89 (1.20) 0.36 (0.48) -0.01 (0.24) 7.9
0.8 0.00 (0.47) 0.00 (0.31) 0.82 (1.20) 0.40 (0.53) -0.03 (0.18) 14.0
SIMEX
0.2 0.05 (0.42) -0.05 (0.31) 0.64 (0.85) 0.52 (0.47) -0.05 (0.28) 0.0
0.6 -0.01 (0.43) -0.07 (0.31) 0.77 (0.90) 0.51 (0.47) -0.10 (0.22) 0.0
0.8 0.00 (0.42) -0.05 (0.31) 0.66 (0.86) 0.52 (0.47) -0.15 (0.17) 0.0
Normal-Normal
Skew-normal 0.2 -0.64 (0.29) 0.17 (0.22) -0.54 (0.38) -0.13 (0.22) 0.03 (0.26) 1.4
(low skewness) 0.6 -0.57 (0.30) 0.00 (0.23) -0.49 (0.40) -0.13 (0.23) -0.11 (0.21) 1.8
0.8 -0.52 (0.31) -0.10 (0.23) -0.44 (0.43) -0.13 (0.22) -0.17 (0.17) 2.1
Binomial-Normal
0.2 -0.54 (0.32) 0.12 (0.23) -0.35 (0.48) -0.05 (0.26) 0.10 (0.33) 5.4
0.6 -0.49 (0.32) -0.05 (0.24) -0.28 (0.53) -0.03 (0.28) 0.03 (0.26) 10.6
0.8 -0.44 (0.34) -0.16 (0.24) -0.18 (0.59) -0.02 (0.29) 0.00 (0.19) 20.0
SIMEX
0.2 -0.48 (0.32) 0.06 (0.24) -0.16 (0.48) 0.11 (0.28) 0.05 (0.27) 0.0
0.6 -0.42 (0.33) -0.11 (0.25) -0.10 (0.51) 0.13 (0.29) -0.09 (0.22) 0.0
0.8 -0.38 (0.33) -0.22 (0.25) -0.04 (0.54) 0.13 (0.30) -0.16 (0.18) 0.0
Normal-Normal
Skew-normal 0.2 -0.59 (0.30) 0.37 (0.20) -0.52 (0.40) -0.19 (0.18) 0.20 (0.23) 1.2
(high skewness) 0.6 -0.44 (0.31) 0.24 (0.22) -0.44 (0.43) -0.15 (0.21) 0.01 (0.18) 1.8
0.8 -0.32 (0.32) 0.15 (0.22) -0.43 (0.44) -0.13 (0.21) -0.11 (0.15) 1.2
Binomial-Normal
0.2 -0.49 (0.32) 0.35 (0.21) -0.30 (0.51) -0.13 (0.21) 0.30 (0.29) 7.6
0.6 -0.33 (0.35) 0.22 (0.23) -0.14 (0.62) -0.06 (0.26) 0.16 (0.20) 15.1
0.8 -0.19 (0.37) 0.13 (0.24) -0.08 (0.66) -0.04 (0.27) 0.05 (0.16) 25.6
SIMEX
0.2 -0.43 (0.32) 0.31 (0.21) -0.13 (0.50) -0.02 (0.22) 0.22 (0.24) 0.0
0.6 -0.26 (0.34) 0.17 (0.23) 0.00 (0.55) 0.06 (0.26) 0.03 (0.19) 0.0
0.8 -0.14 (0.35) 0.08 (0.24) 0.02 (0.57) 0.09 (0.27) -0.10 (0.16) 0.0

Bias and average of the estimated standard errors (s.e.) for the estimators of η¯,ξ¯,ση2,σξ2,ρ, on the basis of 1, 000 replicates with n=10. Failure rates larger than 5% in bold