Table 3.
Potential vmiR target genes were identified using viR-miR database http://alk.ibms.sinica.edu.tw
| v-miRNA | Target gene Abbrev | Target Gene | Gene Product Function | GO term (accession, ontology) |
|---|---|---|---|---|
| hsv1 miR-H1 | HOXC10 | Homeobox C10 | Plays a role in the morphogenesis in multi-cellular organisms. | GO:0003677, Molecular Function |
| hsv1 miR-H1 | MYD88 | Myeloid differentiation primary response gene 88 | Involved with immunity and inflammatory response | GO:0006954, Biological Process |
| hsv1-miR-H1-5p | THBS1 | Thrombospondin 1 | Acts in immediate response to infection or injury causing local vasodilation, extravasation of plasma into intercellular spaces and production of white blood cells and macrophages | GO:0006954, Biological Process |
| hsv1-miR-H1-5p | IL10 | Interleukin 10 | Pleiotropic effects in immunoregulation and inflammation, B-cell survival, proliferation, and antibody production, block nuclear factor kappa B activity | GO:0019969, Molecular Function |
| hsv1-miR-H1-5p | IL8 | Interleukin 8 | Aids in chemotaxis in response to an external stimulus | GO:0006935, Biological Process |
| hsv1-miR-H1-5p | ICOS | Inducible T-Cell Co-Stimulator | Plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation | GO:0052156, Biological Process |
| hsv1-miR-H1-5p | FOS | FBJ murine osteosarcoma viral oncogene homolog | Acts in regulation of transcription | GO:0006355, Biological Process |
| hsv1-miR-H1-5p | CCR9 | C-C chemokine receptor type 9 | Acts with receptor to act as a chemokine | GO:0031734, Biological Process |
| hsv1-miR-H1-5p | CCR7 | C-C chemokine receptor type 7 | Expressed to activate B and T lymphocytes, stimulate dendritic cell maturation, and thought to mediate EBV effects on B lymphocytes | GO:0031732, Molecular Function |
| hsv1-miR-H1-5p | PLCB1 | Phospholipase C, beta 1 | Involved in the metabolism of lipids | GO:0006629, Biological Process |
| hcmv-miR-UL70-3p | ADAM15 | ADAM metallopeptidase domain 15 | Involved in angiogenesis, negative regulation of cell-matrix adhesion, and negative regulation of cell growth | GO:0004896, Molecular Function |
| hcmv-miR-UL70-3p | ATG4A | Autophagy related 4A, cysteine peptidase | Involved with autophagy, transport of cells, and cell homeostasis and remodeling | GO:0006914, Biological Process |
| hcmv-miR-UL70-3p | CCL25 | Chemokine (C-C motif) ligand 25 | Involved with the immune response, cell chemotaxis and chemokine activity | GO:0006955, Biological Process |
| hcmv-miR-UL70-3p | CCR9 | Chemokine (C-C motif) receptor 9 | Acts with receptor to act as a chemokine | GO:0031734, Biological Process |
| hcmv-miR-UL70-3p | FOS | FBJ murine osteosarcoma viral oncogene homolog | Implicated in regulation of transcription, differentiation, and transformation. | GO:0035556, Biological Process |
| hcmv-miR-UL70-3p | GPR64 | G protein-coupled receptor 64 | Involved with cell surface receptor signaling and componentry with the cell membrane | GO:0007166, Biological Process |
| hcmv-miR-UL70-3p | IL10 | Interleukin 10 | Pleiotropic effects in immunoregulation and inflammation, B-cell survival, proliferation, and antibody production, block nuclear factor kappa B activity | GO:0019969, Molecular Function |
| hcmv-miR-UL70-3p | IL8 | Interleukin 8 | Involved in chemotaxis, neutrophil activation, and immune response | GO:0006955, Biological Process |
| hcmv-miR-UL70-3p | IL1a | Interleukin 1, alpha | Involved in generation of fever in response to infection | GO:0001660, Biological Process |
| hcmv-miR-UL70-3p | ICOS | Inducible T cell co-stimulator | Plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation | GO:0052156, Biological Process |
| hcmv-miR-UL70-3p | ICAM1 | Intercellular adhesion molecule 1 | Plays a role in cell membrane componentry | GO:0016021, Cellular Component |
| hcmv-miR-UL70-3p | IL6R | Interleukin 6 receptor | Acts as a cytokine receptor activator | GO:0006954, Biological Process |
| hcmv-miR-UL70-3p | MMP24 | Matrix metalloproteinase 24 | Involved in cell-cell adhesion and cadherin adhesion | GO:0006355, Biological Process |
| hcmv-miR-UL70-3p | PRKCA | Protein kinase C, alpha | Inloved in signal transduction pathways related to cell adhesion and transformation | GO:0001525, Biological Process |
| hcmv-miR-UL70-3p | THBS1 | Thrombospondin 1 | Acts in immediate response to infection or injury causing local vasodilation, extravasation of plasma into intercellular spaces and production of white blood cells and macrophages | GO:0007155: Biological Process |
| kshv-miR-K12-3-5p | ICAM1 | Intercellular adhesion molecule 1 | Plays a role in cell membrane componentry | GO:0016021, Cellular Component |
| kshv-miR-K12-3-5p | ICOS | Inducible T cell co-stimulator | Plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation | GO:0052156, Biological Process |
| kshv-miR-K12-3-5p | GPR64 | G protein-coupled receptor 64 | Acts as in cell surface signaling pathways and in membrane componentry | GO:0007166, Biological Process |
| kshv-miR-K12-3-5p | FOS | FBJ murine osteosarcoma viral oncogene homolog | Implicated in regulation of transcription, differentiation, and transformation. | GO:0006355, Biological Process |
| kshv-miR-K12-3-5p | MRC1 | Mannose receptor, C type 1 | Involved in the recognition of carbohydrates importation in cell-cell recognition and neutralization of pathogens, and viral entry into the host cell | GO:0046718, Biological Process |
| kshv-miR-K12-3-5p | PLCB2 | Phospholipase C, beta 2 | Involved in calcium ion binding and signal transduction | GO:0035556, Biological Process |
| kshv-miR-K12-3-5p | PLCB4 | Phospholipase C, beta 4 | Involved in calcium ion binding and signal transduction | GO:0035556, Biological Process |
| kshv-miR-K12-3-5p | TLR-1 | Toll-like receptor 1 | Associated with regulation of signaling pathways related to innate immunity, and initiate adaptive immunity | GO:0034130, Biological Process |