Table 2.
Comparison between basal clinical and laboratory data of patients with and without acute kidney injury
| AKI present (N = 31) |
AKI absent (N = 52) |
p value | |
|---|---|---|---|
| VTL | 21.60 (15.15 - 26.55) | 13.85 (10.62 - 19.38) | 0.0052* |
| Age | 58 (47 - 72) | 57 (40 - 68) | 0.4978 |
| Sex | 20 (65) | 34 (65) | 0.9360 |
| Weight (kg) | 75 (70 - 80) | 70 (65 - 80) | 0.1022 |
| Serum creatinine (mg/dL) | 1.0 (0.9 - 1.3) | 1.0 (0.8-1.2) | 0.5203 |
| eGFR (mL/min/1.73 m2) | 74.22 (63.53 - 84.90) | 79.55 (70.37 - 88.73) | 0.4589 |
| APACHE II | 20 (11 - 22) | 18 (13 - 22) | 0.8541 |
| SOFA | 8 (6 - 9) | 8 (6 - 9) | 0.8305 |
| Shock | 27 (87) | 37 (71) | 0.1122 |
| Respiratory failure | 26 (84) | 40 (77) | 0.5776 |
| Vancomycin dosage (mg/dia) | 2000 (2000 - 2250) | 2000 (2000 - 3000) | 0.6567 |
| Vancomycin dosage (mg/kg/ia) | 28.6 (25.0 - 33.2) | 30.4 (26.7 - 38.1) | 0.1639 |
AKI - acute kidney injury; VTL - vancomycin trough levels; eGFR - estimated glomerular filtration rate; APACHE II - Acute Physiology and Chronic Health Disease Classification System II; SOFA - Sequential Organ Failure Assessment.
*
Significant differences between patients with and without AKI by the Mann-Whitney test. The results are expressed as median [25 - 75%], number (%) or mean (CI95%).