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Mutations in dsarm block Wallerian degeneration. (A) The lethality of l(3)896, l(3)4621, and l(3)4705 was mapped to region 66B using Exel or Bloomington Stock Center deficiencies. (B) Dsarm protein domains, positions, and effect of predicted point mutations. (C) UAS-dsarm in l(3)896 mutant clones or dsarm+ bacterial artificial chromosome rescue axonal degeneration defects in l(3)896/l(3)4621 flies. n = 12 flies.
