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Histopathology of tissue from CBA/J mouse lungs, stained with mucicarmine at 8 days (A) and 60 days (B) postinfection with C. neoformans strain H99 and viewed by light microscopy. At early stages of the infection, C. neoformans produces a large capsule, which was partially collapsed during tissue handling (arrows in panel A indicate putative capsule edges), whereas at late days the fungus is mainly poorly encapsulated and engulfed within giant cells (B). Magnification, ×40.
