Table 3.
Multivariate Analysis of (a) Leukemia Free Survival and (b) Relapses
| a) | ||
|---|---|---|
| Relative Risk of Relapse or Mortality (95% CI) |
P-Value | |
| Donor type | ||
| MSD* | 1.0 | |
| M-URD | 1.1 (0.5–2.5) | .89 |
| MM-URD | 3.2 (1.3–7.7) | .01 |
| UCB | 1.2 (0.6–2.4) | .68 |
| Length of first remission | ||
| <1 Year* | 1.0 | |
| 1–3 Years | 0.6 (0.3–1.1) | .07 |
| >3 Years | 0.3 (0.2–0.8) | <.01 |
| Grade II–IV acute GVHD | ||
| No* | 1.0 | |
| Yes | 0.4 (0.2–0.9) | .02 |
| b) | ||
|---|---|---|
| Relative Risk of Relapse (95% CI) |
P-Value | |
| Donor type | ||
| MSD* | 1.0 | |
| M-URD | 0.5 (0.1–1.8) | .28 |
| MM-URD | 0.5 (0.1–5.2) | .60 |
| UCB | 0.8 (0.3–2.1) | .71 |
| Length of First Remission | ||
| < 1 Year* | 1.0 | |
| 1–3 Years | 0.7 (0.3–1.8) | .42 |
| >3 Years | 0.2 (0.1–0.7) | .01 |
| Grade II–IV Acute GVHD | ||
| No* | 1.0 | |
| Yes | 0.2 (0.1–0.8) | .03 |
MSD indicates matched related sibling; M-URD, matched unrelated donor; MM-URD, mismatched unrelated donor, UCB, umbilical cord blood; CI, confidence interval, GVHD, graft-versus-host disease.
Legend: the above model is the result of multiple regression analysis on GVHD after testing the following independent variables: donor type, sex, pretransplant conditioning, GVHD prophylaxis, CMV serostatus, age, length of first remission, and type of ALL (T cell versus B cell).
*
Reference category.