Figure 4.

Tremor amplitude can be consistently modulated with phase-specific thalamic stimulation in patients with dystonic tremor. Black bars indicate the median amplitude change at each stimulation phase at the dominant tremor axis, while the red lines show the median amplitude change at the other two tremor axes, which were not phase-tracked to control stimulation. ‘x’ indicates stimulation phases that gave rise to a significant modulation in tremor severity with respect to the no stimulation condition while ‘o’ indicates the stimulation phase that gave rise to the most consistent change in tremor amplitude across all trials. Significance was tested with respect to the surrogate distribution derived from the no stimulation condition, and corrected for 12 effective comparisons using Bonferroni correction. Note that, for presentation purposes, median stimulation phase-amplitude relationships have been smoothed using a moving average filter with a span of three stimulation phases. However, all ranges presented in the main text, and statistical analyses involved data prior to smoothing.