Figure 1.
The location of the OPP binding site in complex with the 12-lipoxygenase catalytic domain. A. A semitransparent surface representation of the catalytic domain indicates where OPP was found in the 2Fo-Fc map of the catalytic domain. The position of the N-terminal domain modeled from the structure of 15-lipoxygenase is presented in green. The maroon helix represents the position of helix α2. B. A cutaway surface representation shows the 2Fo-Fc map and the structure of OPP. The orange sphere indicates the position of the iron atom. The red sphere indicates the position of the iron-associated water/hydroxide. The 2Fo-Fc maps were contoured at 1.5 σ.