Table 4.
Pharmacokinetic parameters for perfluorobutane (PFB) and perfluoromethylcyclopentane (PF‐MCP) measured in whole blood from the dogs. Values given are mean ± SD. No statistical differences between animals exposed or not exposed to ultrasound were detected
| Group | Test item | Dose (mL/kg) | US activation | PFB | PF‐MCP | ||||
|---|---|---|---|---|---|---|---|---|---|
| C max (ng/g) | AUClast (min × ng/g) | Half‐life (min) | Cmax (ng/g) | AUClast (min × ng/g) | Half‐life (min) | ||||
| 1 | Saline | 1.0 | No | N/A | N/A | N/A | N/A | N/A | N/A |
| 2 | ACT | 0.1 | No | 27.8 ± NC | 259 ± 50.3 | 4.8 ± 1.5 | 1894 ± NC | 22826 ± 2929 | 115 ± 5.6 |
| 3 | ACT | 0.3 | No | 69.1 ± 16.9 | 647 ± 128 | 22.1 ± 1.7 | 4059 ± 1143 | 59179 ± 15752 | 93.2 ± 32.1 |
| 4 | ACT | 1.0 | No | 165 ± 73.6 | 1660 ± 550 | 20.1 ± 2.4 | 9034 ± 4111 | 135960 ± 30405 | 54.8 ± 7.8 |
| 5 | Saline | 1.0 | Yes | N/A | N/A | N/A | N/A | N/A | N/A |
| 6 | ACT | 0.1 | Yes | 27.8 ± 3.2 | 295 ± 62.8 | 6.3 ± 4.0 | 2086 ± 354 | 34477 ± 13014 | 110 ± 30.4 |
| 7 | ACT | 0.3 | Yes | 53.0 ± NC | 518 ± 117 | 21.2 ± 1.4 | 3868 ± NC | 49019 ± 10378 | 69.8 ± 9.6 |
| 8 | ACT | 1.0 | Yes | 160 ± 45.8 | 1946 ± 413 | 18.9 ± 4.0 | 9607 ± 3937 | 162475 ± 34426 | 58.1 ± 8.4 |
NC: not calculable since some animals were excluded from calculations due to T max > 2 min. ACT, Acoustic Cluster Therapy.