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. 2016 Nov 7;4(6):e00275. doi: 10.1002/prp2.275

Figure 2.

Figure 2

LY2940094 decreased immobility or float time in wild‐type mice (unfilled bars) but was devoid of activity in NOP receptor knockout mice (filled bars). Imipramine was active in the mouse‐forced swim test in both genotypes. Mice were dosed p.o. with LY2940094 (30 mg/kg) then tested 60 min later. IMI: 15 mg/kg, 30 min prior i.p. Wildtype: vehicle and LY2940094 (n = 10); imipramine (n = 3). Knockout: vehicle (n = 11), LY2940094 (n = 9), imipramine (n = 4). *P < 0.05 versus wildtype vehicle; **P < 0.05 versus wildtype LY2940094; ***P < 0.01 versus knockout vehicle. NOP, nociceptin receptor.