Skip to main content
. Author manuscript; available in PMC: 2017 Nov 1.
Published in final edited form as: Anesthesiology. 2016 Nov;125(5):1030–1043. doi: 10.1097/ALN.0000000000001336

Figure 2. Systemic administration of CX546 relieves mechanical hypersensitivity in paw incision (PI)-treated rats.

Figure 2

A. Intraperitoneal administration of CX546 relieved mechanical hypersensitivity in PI-treated rats at doses of 5mg/kg and 10mg/kg, compared with Dimethyl sulfoxide (DMSO). One-way ANOVA with post hoc Bonferroni multiple comparison tests, DMSO group n=12; CX546 2.5mg/kg group n=7; CX546 5mg/kg group n=7; CX546 10mg/kg group n=6, *p=0.0404, ****p<0.0001. B. A single dose of CX546 (10mg/kg) improved mechanical hypersensitivity in PI-treated rats at 1, 2 and 4 hour after intraperitoneal injection, compared with the DMSO control group. Two-way ANOVA with repeated measures, DMSO group n=13, CX546 group n=13, *p=0.0300, **p=0.0031, ****p<0.0001.