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. Author manuscript; available in PMC: 2017 Nov 1.
Published in final edited form as: Anesthesiology. 2016 Nov;125(5):1030–1043. doi: 10.1097/ALN.0000000000001336

Figure 4. Local infusion of CX546 into the nucleus accumbens (NAc) relieves mechanical hypersensitivity in paw incision (PI)-treated rats.

Figure 4

A. Schematic showing the timeline of pharmacological experiments. B. Intra-NAc infusion of CX546 (400uM/ul) on 4 hours and 1 day after paw incision reduced mechanical hypersensitivity in PI-treated rats. Two-way ANOVA with Bonferroni post-test, Saline group n=6, CX546 group n=8, *p=0.0248, **p=0.0012. C. Intra-NAc infusion of 3-dihydroxy-6-nitro-7-sulfamoyl-benzo[f]quinoxaline-2, 3-dione (NBQX) blocked the analgesic effects of systemic administration of CX546 (10mg/kg) in PI-treated rats. Unpaired two-tailed Student's t-test, Saline group n=8; NBQX group n=8, **p=0.0046.