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. Author manuscript; available in PMC: 2017 Jan 11.
Published in final edited form as: Behav Brain Res. 2015 Jun 16;292:83–94. doi: 10.1016/j.bbr.2015.06.023

Figure 1. Comparison of Barnes maze test and synaptic protein expressions in hippocampus of B6 and D2 strains with high fat diet-induced obesity.

Figure 1

(A) The Barnes maze was used to test spatial memory acquisition and retention. Performance improved significantly in all groups over the course of training. Although experimental groups did not differ on the measures of total errors, D2+HFD mice had a higher number of visits to incorrect holes before reaching the target hole. Data are presented in mean ± SEM of four trials per day (n=8–10 per group). (B) Homogenates of the hippocampi of mice were analyzed by Western blots developed with the indicated antibodies; each lane represents an individual mouse sample. (C) Quantitative analysis of densitometrical data from western blots after normalization with the β-actin. The corresponding protein levels are presented as mean ± SEM (n = 4/group); statistical analysis is described in the results section, *p < 0.05.