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. Author manuscript; available in PMC: 2017 Jan 11.
Published in final edited form as: Behav Brain Res. 2015 Jun 16;292:83–94. doi: 10.1016/j.bbr.2015.06.023

Figure 6. HFD-induced gene expression changes in the hippocampus of obesity-resistant strain (BXD77), obesity-prone strain (BXD66), and parental B6 and D2 strains.

Figure 6

(A) Changes in hippocampal mRNA expression of neuro inflammation cytokines, from left to right, interleukin (IL)-6, IL-1β, and ICAM-1. (B) Synaptic plasticity markers ChAT, GAP43, and Egr-1. (C) Down Syndrome-related genes Dscr1L, Dscr3, and DSCAM. (D) Obesity related genes Lep and LRP1. Data are expressed as means ± SEM (n = 3 per group, duplicate experiments were performed).The relative transcript levels were normalized to the expression level of GAPDH mRNA. *, p<0.05, **, p<0.01, ***, p<0.001, and ****, p<0.0001.