Table 2. GO/Pathway analysis.
| GO terms enriched for PIP3-specific binding proteins (total) | |||
|---|---|---|---|
| Term | Count | Fold Δ | FDR |
| Translation | 107 | 7.4 | 5E–65 |
| Protein biosynthesis | 40 | 2.4 | 2E–43 |
| Positive regulation of growth | 109 | 2.0 | 7E–25 |
| Adult life-span determination / Aging | 46 | 3.3 | 1E–10 |
| Proteasome core complex | 18 | 2.8 | 1E–10 |
| Proteasome component region PCI | 6 | 2.2 | 1E–9 |
| Stress response | 6 | 5.9 | 4E–6 |
| Unfolded protein response | 3 | 2.8 | 6E–6 |
| Mitochondria / Cellular respiration | 14 | 5.6 | 1E–5 |
| Lipid transport | 4 | 2.9 | 3E–3 |
Functional-annotation enrichment (https:/david.ncifcrf.gov/) was analyzed for proteins recovered from PIP3-affinity beads and identified by LC-MS/MS. Count: total proteins per category. Fold Δ: term enrichment factor. FDR: False Discovery Rate (<0.05 is considered significant).