Table 5. Multiple benefits of PIP3-binding candidate knockdowns.
| Gene | H2O2 survival | Aβ1–42 aggreg. | α-synuclein aggregation | Longevity effect (range) or reference |
|---|---|---|---|---|
| induced aging | ||||
| rad-50 | ↑5x | ↓3x ↓10x | ↓3.6x | ↑15% (8 – 20%) |
| cand-1 | ↑11x | ↓5x ↓20x | N.S. | ↑17% (15 – 19%) |
| fat-2 | ↑5x | ↓4x ↓20x | ↓40% | ↑ [40] |
| akt-1 | ↑9x | N.S. ↓3x | N.S. | ↑9%; [45] |
| tct-1 | ↑7x | N.S. N.S. | ↓ 2x |
N.S., not significant; grey shading, not tested here. Reference citations indicate published lifespan data.