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. 2016 Jun 30;7(31):48887–48904. doi: 10.18632/oncotarget.10346

Figure 6. Regulation of rRNA synthesis by amino acids and growth factors.

Figure 6

Schematic diagram of the signaling network mediating cooperative regulation of rDNA transcription by amino acids and growth factors. Growth factor activation of AKT signaling primes rDNA transcription initiation, and amino acids promote rDNA transcription elongation, rRNA processing and the synthesis of mature rRNAs via mTORC1/S6K1 and MYC signaling.PI3K: Phosphotidylinositol 3- kinase; mTORC1: mammalian target of rapamycin complex 1; S6K1: ribosomal protein S6 kinase 1.