Figure 1. Desferal synergistically interacts with platinum drugs and increases platinum–DNA adduct formation in oxaliplatin-resistant S3 cells.

(A–D) Measurement of platinum–DNA adduct formation in cells treated with 1-fold of IC₅₀ of platinum drugs (refer to Table 1) and desferal, as described in the Materials and Methods section. Each value is presented as the mean ± standard deviation (SD) of three independent experiments (P < 0.05).