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. 2016 Jun 30;7(31):49310–49321. doi: 10.18632/oncotarget.10336

Figure 4. TfR1 promoted DNA adduct formation through Sp1.

Figure 4

(A) Sp1 or TfR1-targeted were transfected into SiHa and S3 cells, respectively. 5-fold of IC50 platinum drugs including oxaliplatin, cisplatin, and carboplatin were incubated with cells for performing ELISA assay (P < 0.05), as described in Materials and Methods section. (B) SiHa cells were transfected with TfR1- or hCtr1-targeted siRNA for comparing the efficiency of transporting platinum drugs for performing ELISA assay (P < 0.05).