Table 2. Combination effect of desferal and platinum drugs, including oxaliplatin, cisplatin, and carboplatin, on SiHa and S3 cells.

Drugs	SiHa	S3
	Combination Index (CI)
Oxaliplatin + Desferal	1.76	0.51
Cisplatin + Desferal	1.18	0.68
Carboplatin + Desferal	1.37	0.93

The drug combination analysis was performed using the Chou and Talalay method. Graphs representing values of combination index (CI) versus fractional effect were automatically generated using CalcuSyn software. Effect is the fraction of cell death induced by drug treatment and ranges from 0 to 1, with 0 representing no cell death and 1 representing 100% cell death. The quantitative CI value defines addictive effect as CI = 1, synergism as CI < 1, and antagonism as CI > 1 in a combination of two drugs.