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. 2016 Jun 7;7(31):49349–49367. doi: 10.18632/oncotarget.9885

Figure 4. CCL2 gene silencing enhances necrosis and autophagy in MDA-MB-231 breast tumor xenografts.

Figure 4

MDA-MB-231 breast tumor xenografts were injected with Ca-TAT peptides complexed to control siRNAs (Con), or CCL2 siRNAs (huCCL2si1 or huCCL2si2), and immunostained for expression of A. PCNA, B. Cleaved caspase-3, C. HMGB1, or D. LC3B. Scale=100 microns. Statistical analysis was performed by One Way ANOVA followed by Bonferonni post-hoc analysis. Statistical significance was determined by p-value less than 0.05. *p<0.05, ***p<0.001, n.s=not significant. Mean+SEM is shown. N=6 animals per group.