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. 2016 Jun 7;7(31):49349–49367. doi: 10.18632/oncotarget.9885

Figure 6. CCL2 gene silencing in MDA-MB-231 breast tumor xenografts inhibits M2 macrophage recruitment but not tumor angiogenesis.

Figure 6

MDA-MB-231 breast tumor xenografts were examined for A. CD11b expression by flow cytometry, B. Arginase I, or C. Von Willebrand Factor 8 (VWF8) expression, by immunohistochemistry. Scale bar=100 microns. Expression levels were quantified by Image J; arbitrary units are shown. Statistical analysis was performed by One Way ANOVA followed by Bonferonni post-hoc comparisons with Control group. Statistical significance was determined by p-value less than 0.05. *p<0.05, **p<0.01, n.s= not significant. Mean+SEM is shown. N=6 animals per group