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. 2016 Jun 30;7(31):49368–49383. doi: 10.18632/oncotarget.10343

Figure 4. Ectopic Lin28B expression promotes the stem cell phenotype and inhibits glial phenotype of Müller cells in vitro.

Figure 4

(A–A9) Clone formation efficiency of cultured Müller cells treated with Ad/Lin28B was higher than that treated with Ad/GFP. Both self-renewal ability (A8) and proliferation (A9) of Ad/Lin28B infected group were significantly stronger compared with the Ad/GFP infected group. (B–B2) DNA content analysis of Müller cells treated with Ad/Lin28B or Ad/GFP by flow cytometry. There was a significant increase in the percentage of S phase in Müller cells treated with Ad/Lin 28B compared with those treated with Ad/GFP. Representative results are shown. Data are presented as the mean ± standard error from three replicates. *P < 0.05, **P < 0.01, Student's t-test.