Table 2. Influence of SEP combined 5-Fu treatment on haemopoietic function in LLC-bearing mice.
| Group | Dosage (mg/kg) | WBC (×109) | RBC (×1012) | PLT(×109) | RC (×1012) | CD34+ (%) |
|---|---|---|---|---|---|---|
| Model | 7.14 ± 1.23 | 5.68 ± 1.35 | 280.09 ± 66.81 | 0.67 ± 0.25 | 2.09 ± 0.12 | |
| 5-FU | 6.25 | 4.45 ± 1.60 | 5.96 ± 1.66 | 262.67 ± 54.98 | 0.27 ± 0.03## | 1.94 ± 0.07 |
| 12.5 | 3.48 ± 0.73## | 5.68 ± 1.35 | 214.86 ± 45.96# | 0.18 ± 0.01## | 1.15 ± 0.07## | |
| 25 | 1.41 ± 0.15## | 3.71 ± 1.17## | 142.00 ± 25.09## | 0.04 ± 0.01## | 0.92±0.08## | |
| 5-FU + SEP | 6.25 + 10 | 5.43 ± 0.63 | 6.61 ± 0.81 | 282.67 ± 71.97 | 0.48 ± 0.15** | 1.85 ± 0.09 |
| 12.5 + 10 | 6.49 ± 1.61** | 6.07 ± 1.57 | 241.33 ± 46.46 | 0.57 ± 0.14** | 1.69 ± 0.17#** | |
| 25 + 10 | 4.84 ± 0.23##** | 5.33 ± 0.26** | 227.39 ± 48.78** | 0.36 ± 0.12##** | 1.54 ± 0.08#** |
The data were shown as mean ± SD,
#
P < 0.05,
##
P < 0.01, compared with model group.
*
P < 0.05,
**
P < 0.01, compared with the corresponding dose of the 5-FU group.