Figure 2. Viability after 24 hours of combination treatment of ara-C and IAP inhibitor BV6 in primary AML samples.

Combination of ara-C (increasing doses as indicated) with BV6 (single dose: 2 μM), according to the respective ara-C response group (sensitive (A, B), intermediate (C, D), resistant (E, F), see also Figure 1) and the achieved effect of the combination (more than additive (A, C, E) or additive and less than additive (B, D, F)). Mean and SD of all samples in the respective group (sample size as indicated in each graph) are shown, with the three curves representing ara-C single treatment, combination of ara-C with a constant dose of 2 μM BV6 (measured ara-C+BV6), and the theoretical viability of this combination, as defined by the Bliss independence rule (theoretical ara-C + BV6).