Table 1. Proteins up regulated in HR UM only.
| Accession | Unique peptides | Confidence score | Description | Secretory mechanism | Fold change HR vs LR |
|---|---|---|---|---|---|
| O15240 | 21 | 1487.97 | Neurosecretory protein VGF GN = VGF | C | 42.0 |
| P48745 | 9 | 638.09 | Protein V homolog GN = V | C | 14.7 |
| P35442 | 17 | 961.28 | Thrombospondin-2 GN = THBS2 | C | 8.0 |
| P16112 | 5 | 271.05 | Aggrecan core protein GN = ACAN | C | 6.0 |
| O60462 | 7 | 343.53 | Neuropilin-2 GN = NRP2 | C | 4.5 |
| P19021 | 7 | 380.95 | Peptidyl-glycine alpha-amidating monooxygenase GN = PAM | C | 4.0 |
| Q92743 | 7 | 442.47 | Serine protease HTRA1 GN = HTRA1 | C | 3.0 |
| P05121 | 7 | 470.84 | Plasminogen activator inhibitor 1 GN = SERPINE1 | C | 2.9 |
| P25391 | 13 | 648.55 | Laminin subunit alpha-1 GN = LAMA1 | C | 2.7 |
| P02462 | 5 | 405.57 | Collagen alpha-1(IV) chain GN = COL4A1 | C | 2.5 |
| P29279 | 10 | 494.08 | Connective tissue growth factor GN = CTGF | C | 2.5 |
| Q16610 | 14 | 720.42 | Extracellular matrix protein 1 GN = ECM1 | C | 2.4 |
| Q16270 | 14 | 1280.19 | Insulin-like growth factor-binding protein 7 GN = IGFBP7 | C | 2.4 |
| P29120 | 7 | 420.62 | Neuroendocrine convertase 1 GN = PCSK1 | NC | 16.2 |
| P98155 | 4 | 166.49 | Very low-density lipoprotein receptor GN = VLDLR | NC | 6.0 |
| Q9UBG0 | 5 | 213.11 | C-type manse receptor 2 GN = MRC2 | NC | 4.2 |
| Q9Y639 | 3 | 146.05 | Neuroplastin GN = NPTN | NC | 2.3 |
| P05067 | 12 | 675.22 | Amyloid beta A4 protein GN = APP | NC | 2.1 |
| P00736 | 5 | 344.66 | Complement C1r subcomponent GN = C1R | E | 9.0 |
| P09871 | 10 | 600.05 | Complement C1s subcomponent GN = C1S | E | 6.1 |
| O00161 | 3 | 118.77 | Synaptosomal-associated protein 23 GN = SNAP23 | E | 4.8 |
| Q06481 | 17 | 976.38 | Amyloid-like protein 2 GN = APLP2 | E | 3.9 |
| P34896 | 3 | 144.82 | Serine hydroxymethyltransferase, cytosolic GN = SHMT1 | E | 3.9 |
| O75955 | 4 | 315.33 | Flotillin-1 GN = FLOT1 | E | 3.8 |
| Q9NZM1 | 22 | 1209.91 | Myoferlin GN = MYOF | E | 3.3 |
| Q86UX7 | 4 | 217.02 | Fermitin family homolog 3 GN = FERMT3 | E | 3.3 |
| P08582 | 7 | 342.22 | Melanotransferrin GN = MFI2 | E | 2.9 |
| P16070 | 5 | 361.46 | CD44 antigen GN = CD44 | E | 2.6 |
| O60568 | 8 | 446.68 | Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 GN = PLOD3 | E | 2.3 |
| O00159 | 8 | 409.62 | Unconventional myosin-Ic GN = MYO1C | E | 2.2 |
| P11717 | 22 | 1134.74 | Cation-independent mannose-6-phosphate receptor GN = IGF2R | E | 2.2 |
| P06756 | 4 | 185.83 | Integrin alpha-V GN = ITGAV | E | 2.1 |
| Q14697 | 6 | 400.91 | Neutral alpha-glucosidase AB GN = GANAB | E | 3.4 |
C = Classical secretion; NC = Non-classical secretion; E = exosomal.