Figure 2. Effects of DAS and DAS-loaded NPs on K562 cell viability and modulation of Lyn kinase.

K562 cells were treated with DMSO, NPs, DAS (100 nM) or DAS-loaded NPs (DAS-NPs, 100 nM as DAS). (A) Cell viability was assessed by growth inhibition assay at 72 h after exposure. (B) Representative blots of phosphorylated Lyn (p-Lyn) and total Lyn (Lyn) kinases 2 h after the treatment. (C) Densitometry analysis is presented as relative ratios of p-Lyn to Lyn. Data were expressed as mean ± SEM. The experiments were repeated three times. *P < 0.05 versus DMSO group.