Table 3. Multivariate Cox regression analysis of HCC recurrence.
| Variable | Within 1 year | Within 2 years | Overall | |||
|---|---|---|---|---|---|---|
| Hazard ratio (95% CI) | P-value | Hazard ratio (95% CI) | P-value | Hazard ratio (95% CI) | P-value | |
| Sex | 0.05 (0.01 - 0.36) | 0.003 | 0.22 (0.06 - 0.80) | 0.021 | 0.61 (0.12 - 3.18) | .554 |
| Age | 1.05 (0.97 - 1.14) | 0.208 | 1.03 (0.97 - 1.09) | 0.348 | 1.03 (0.96 - 1.11) | .384 |
| Alcohol | 0.18 (0.01 - 2.83) | 0.221 | 0.29 (0.06 - 1.54) | 0.147 | 0.74 (0.06 - 8.51) | .809 |
| Smoking | 0.30 (0.03 - 4.32) | 0.314 | 0.76 (0.20 - 2.81) | 0.675 | 0.44 (0.05 - 3.85) | .462 |
| Fatty liver | 1.13 (0.30 - 4.32) | 0.854 | 0.48 (0.18 - 1.29) | 0.145 | 0.26 (0.06 - 1.21) | .087 |
| HBV infection | 13.16 (1.07 - 162.15) | 0.044 | 2.55 (0.73 - 8.88) | 0.142 | 2.41 (0.34 - 16.82) | .376 |
| HCV infection | 15.74 (1.08 - 229.90) | 0.044 | 3.14 (0.74 - 13.26) | 0.119 | 1.93 (0.23 - 15.86) | .541 |
| Liver cirrhosis | 0.84 (0.25 - 2.84) | 0.783 | 1.20 (0.46 - 3.09) | 0.711 | 3.93 (0.74 - 20.86) | .108 |
| α-fetoprotein | 1.00 (1.00 - 1.00) | 0.632 | 1.00 (1.00 - 1.00) | 0.671 | 1.00 (1.00 - 1.00) | .740 |
| TNM stage | 11.31 (3.13 - 40.94) | < 0.001 | 7.71 (3.17 - 18.74) | < 0.001 | 5.77 (1.77 - 18.82) | .004 |
| GLK proportion score in non-cancerous tissue | 2.59 (1.33 - 5.02) | 0.005 | 2.18 (1.38 - 3.44) | < 0.001 | 3.06 (1.45 - 6.49) | .003 |
| pIKK proportion score in non-cancerous tissue | 0.98 (0.62 - 1.52) | 0.913 | 1.24 (0.87 - 1.77) | 0.233 | 2.22 (1.16 - 4.26) | .017 |
Abbreviations: CI, confidence interval; HBV, hepatitis B virus; HCC, hepatocellular carcinoma; HCV, hepatitis C virus; pIKK, phosphorylated inhibitor of nuclear factor kappa B kinase.