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. 2016 Jul 6;7(31):49786–49799. doi: 10.18632/oncotarget.10448

Figure 5. Effect of FLT3 inhibition in the cytotoxicity induced by Ara-C.

Figure 5

Cell viability was determined by MTT assays when (A) MV4-11 and SEM cells were cultured with Ara-C (3 μM and 1 μM for MV4-11 and SEM cells respectively) either in the presence or not of NBTI (1 μM) or phloridzin (250 μM) for 48 h; (B) MV4-11 cells were treated with the FLT3 inhibitor PCK412 (16 h), followed by a 6 h exposure to Ara-C (10 μM), and (C) MV4-11 cells were cultured with Ara-C (10 μM) for 6 h, followed by a 16 h exposure to PKC412. Data are expressed as percentage of survival ± SEM of triplicate measurements from six-nine independent experiments. Statistical significance denotes significant difference relative to control cells (*p < 0.1; **p < 0.01; ***p < 0.001) or to Ara-C or PKC412 treated cells as indicated.