MetaCore ontology analysis of differentially expressed genes identified by RNA-seq following 3-hour treatment of BJ-T p53sh cells with 5 nM Act D.
| Enrichment analysis report | ||||
|---|---|---|---|---|
| Enrichment by Pathway Maps | 3h ActD | |||
| # | Maps | Total | p - value | In Data |
| 1 | Immune response_IL-1 signaling pathway | 44 | 3.048E-08 | 12 |
| 2 | Apoptosis and survival_APRIL and BAFF signaling | 39 | 7.918E-08 | 11 |
| 3 | Immune response_TLR2 and TLR4 signaling pathways | 57 | 8.307E-08 | 13 |
| 4 | Immune response_IL-17 signaling pathways | 60 | 1.589E-07 | 13 |
| 5 | Signal transduction_NF-kB activation pathways | 51 | 1.826E-07 | 12 |
| 6 | Immune response_TNF-R2 signaling pathways | 45 | 3.947E-07 | 11 |
| 7 | Immune response_CD40 signaling | 65 | 4.289E-07 | 13 |
| 8 | Expression targets of Tissue factor signaling in cancer | 22 | 5.512E-07 | 8 |
| 9 | Immune response_Signaling pathway mediated by IL-6 and IL-1 | 30 | 6.927E-07 | 9 |
| 10 | Immune response_TLR5, TLR7, TLR8 and TLR9 signaling pathways | 48 | 7.970E-07 | 11 |
RNA was extracted from three biological replicates. The most significantly enriched gene ontologies are represented. p-value denotes the significance of the number of differentially expressed genes (In Data) compared to the total number of genes (Total) in the gene ontology classification.