Table 1. Cohort and tumor characteristics by deprivation category, n (%) and mean [standard deviation] for continuous variables.
| N=20,265 | Least deprived 1 | 2 | 3 | 4 | Most deprived 5 | Total | p-value (χ2) |
|---|---|---|---|---|---|---|---|
| Age at diagnosisa | |||||||
| Mean [sd] | 57.2 [4.9] | 57.6 [5.1] | 57.5 [5.0] | 57.5 [5.1] | 57.7 [5.1] | 57.5 [5.0] | 0.040 |
| 50-54 | 1,576 (35.2) | 1,556 (33.7) | 1,407 (33.7) | 1,218 (34.3) | 1,122 (32.5) | 6,879 (33.9) | |
| 55-59 | 1,442 (32.2) | 1,412 (30.6) | 1,307 (31.3) | 1,084 (30.6) | 1,089 (31.6) | 6,334 (31.3) | |
| 60-64 | 1,042 (23.3) | 1,141 (24.7) | 990 (23.7) | 847 (23.9) | 840 (24.3) | 4,860 (24.0) | |
| 65-70 | 418 (9.3) | 505 (10.9) | 472 (11.3) | 397 (11.2) | 400 (11.6) | 2,192 (10.8) | |
| Vital status at end of follow up | |||||||
| Alive | 3752 (83.8) | 3854 (83.5) | 3421 (81.9) | 2810 (79.2) | 2699 (78.2) | 16,536 (81.6) | <0.001 |
| Dead | 726 (16.2) | 760 (16.5) | 755 (18.1) | 736 (20.8) | 752 (21.8) | 3,729 (18.4) | |
| Screening historyb | |||||||
| SD | 2,320 (51.8) | 2,380 (51.6) | 2,232 (53.4) | 1,830 (51.6) | 1,740 (50.4) | 10,502 (51.8) | 0.120 |
| Not SD | 2,158 (48.2) | 2,234 (48.4) | 1,944 (46.6) | 1,716 (48.4) | 1,711 (49.6) | 9,763 (48.2) | |
| Period of diagnosisa | |||||||
| 1989-1994 | 200 (4.5) | 167 (3.6) | 161 (3.9) | 136 (3.8) | 137 (4.0) | 801 (4.0) | <0.001 |
| 1995-2000 | 934 (20.9) | 866 (18.8) | 787 (18.8) | 651 (18.4) | 600 (17.4) | 3,838 (18.9) | |
| 2001-2006 | 1,765 (39.4) | 1,781 (38.6) | 1,555 (37.2) | 1,383 (39.0) | 1,300 (37.7) | 7,784 (38.4) | |
| 2007-2011 | 1,579 (35.3) | 1,800 (39.0) | 1,673 (40.1) | 1,376 (38.8) | 1,414 (41.0) | 7,842 (38.7) | |
| Extent of disease | |||||||
| Local | 2,786 (62.2) | 2,795 (60.6) | 2,539 (60.8) | 2,048 (57.8) | 2,002 (58.0) | 12,170 (60.1) | <0.001 |
| Regional | 1,305 (29.1) | 1,435 (31.1) | 1,303 (31.2) | 1,169 (33.0) | 1,146 (33.2) | 6,358 (31.4) | |
| Distant | 98 (2.2) | 97 (2.1) | 78 (1.9) | 106 (3.0) | 104 (3.0) | 483 (2.4) | |
| Missing | 289 (6.5) | 287 (6.2) | 256 (6.1) | 223 (6.3) | 199 (5.8) | 1,254 (6.2) | |
| Histological group | |||||||
| Ductal | 3,274 (73.1) | 3,297 (71.5) | 2,962 (70.9) | 2,475 (69.8) | 2,497 (72.4) | 14,505 (71.6) | 0.001 |
| Lobular | 673 (15.0) | 784 (17.0) | 690 (16.5) | 581 (16.4) | 486 (14.1) | 3,214 (15.9) | |
| All other | 509 (11.4) | 512 (11.1) | 503 (12.0) | 463 (13.1) | 442 (12.8) | 2,429 (12.0) | |
| Missing | 22 (0.5) | 21 (0.5) | 21 (0.5) | 27 (0.8) | 26 (0.8) | 117 (0.6) | |
| Grade of tumor | |||||||
| I | 932 (20.8) | 932 (20.2) | 858 (20.5) | 692 (19.5) | 671 (19.4) | 4,085 (20.2) | 0.260 |
| II | 1,897 (42.4) | 2,027 (43.9) | 1,778 (42.6) | 1,537 (43.3) | 1,436 (41.6) | 8,675 (42.8) | |
| III | 1,292 (28.9) | 1,286 (27.9) | 1,222 (29.3) | 1,019 (28.7) | 1,072 (31.1) | 5,891 (29.1) | |
| Missing | 357 (8.0) | 369 (8.0) | 318 (7.6) | 298 (8.4) | 272 (7.9) | 1,614 (8.0) | |
| Size of tumor (mm) a, c | |||||||
| Mean [sd] | 20.1 [15.4] | 20.5 [15.7] | 21.1 [17.5] | 21.4 [17.1] | 22.4 [17.4] | 21.0 [16.6] | <0.001 |
| 0 - 20 | 2,490 (55.6) | 2,486 (53.9) | 2,242 (53.7) | 1,839 (51.9) | 1,707 (49.5) | 10,764 (53.1) | |
| 20 - 50 | 1,380 (30.8) | 1,484 (32.2) | 1,387 (33.2) | 1,183 (33.4) | 1,251 (36.3) | 6,685 (33.0) | |
| 50 mm+ | 211 (4.7) | 237 (5.1) | 226 (5.4) | 199 (5.6) | 215 (6.2) | 1,088 (5.4) | |
| Missing | 397 (8.9) | 407 (8.8) | 321 (7.7) | 325 (9.2) | 278 (8.1) | 1,728 (8.5) | |
| Charlson score | |||||||
| 0 | 4,301 (96.0) | 4,444 (96.3) | 3,991 (95.6) | 3,345 (94.3) | 3,199 (92.7) | 19,280 (95.1) | <0.001 |
| 1 | 77 (1.7) | 90 (2.0) | 99 (2.4) | 100 (2.8) | 151 (4.4) | 517 (2.6) | |
| 2 | 92 (2.1) | 71 (1.5) | 68 (1.6) | 84 (2.4) | 77 (2.2) | 392 (1.9) | |
| 3 | 8 (0.2) | 9 (0.2) | 18 (0.4) | 17 (0.5) | 24 (0.7) | 76 (0.4) | |
| Surgery | |||||||
| No | 288 (6.4) | 306 (6.6) | 252 (6.0) | 289 (8.2) | 279 (8.1) | 1,414 (7.0) | <0.001 |
| Yes | 4,190 (93.6) | 4,308 (93.4) | 3,924 (94.0) | 3,257 (91.8) | 3,172 (91.9) | 18,851 (93.0) | |
| Total | 4,478 (100) | 4,614 (100) | 4,176 (100) | 3,546 (100) | 3,451 (100) | 20,265 (100) | |
| Time from diagnosis to first surgerya (among those who had surgery, n=18,851) | |||||||
| Mean [sd] (days) | 21.6 [23.6] | 22.6 [24.9] | 22.1 [23.4] | 23.5 [25.5] | 23.5 [25.2] | 22.6 [24.5] | |
| 0 – 2 weeks | 1,557 (37.2) | 1,530 (35.5) | 1,313 (33.5) | 1,036 (31.8) | 992 (31.3) | 6,428 (34.1) | <0.001 |
| 2 - 6 weeks | 2,317 (55.3) | 2,408 (55.9) | 2,336 (59.5) | 1,934 (59.4) | 1,914 (60.3) | 10,909 (57.9) | |
| 6 + weeks | 289 (6.9) | 341 (7.9) | 250 (6.4) | 270 (8.3) | 248 (7.8) | 1,398 (7.4) | |
| Missing | 27 (0.6) | 29 (0.7) | 25 (0.6) | 17 (0.5) | 18 (0.6) | 116 (0.6) | |
| Total | 4,190 (100) | 4,308 (100) | 3,924 (100) | 3,257 (100) | 3,172 (100) | 18,851 (100) | |
a
Fitted as a continuous variable in the model
b
SD=screen detected, not SD=not screen-detected
c
Grouped here according to TNM criteria: T1 >=20 mm, T2 20mm-50 mm, T3 >=50 mm [45].