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. 2016 Jul 13;7(31):50086–50098. doi: 10.18632/oncotarget.10574

Figure 5. Colorectal cancer exosomes induce the umbilicated spheroids formation in ccMSCs.

Figure 5

(A) Proliferation rate of cMSCs spheroids compared with that of ccMSCs ones, incubated with pCRCexo or mCRCexo for 72 h; (B) Measurements of the volume of ccMSC spheroids formed after the pCRCexo or mCRCexo treatment at 72 h respect to untreated ccMSCs (CTR). Statistical analysis were performed by unpaired Student t-test, between untreated cMSCs or ccMSCs (CTR) and +pCRCexo, CTR and +mCRCexo, +pCRCexo and +mCRCexo (**p≤ 0.005; ***p < 0.001). (C) CLSM images of ccMSCs spheroids untreated or treated with pCRCexo or mCRCexo for 72 hours.V-ATPase protein expression was reported in white, nuclei are reported in blue (DAPI). Scale bars, 20 μM.