Figure 3. The overexpression of miR-29c enhanced TMZ sensitivity in vivo.

A. Size of subcutaneous tumor growth after injection of scramble-transfected and miR-29c-transfected resistant U251/TR cells and sensitive U251 cells, then followed by TMZ therapy or DMSO for 4 weeks. Tumor size was assessed every four days. *, P < 0.05, **, P < 0.01. B-C. After four consecutive weeks of therapy, the mice were euthanized and the wet weights of the tumors were recorded. Representative images of xenografts (C) and a summary of tumor weight in nude mice (B). *, P < 0.05, **, P < 0.01. All results are expressed as the mean ± SD of three independent experiments.