Figure 8. Assessment of the therapeutic benefit of adding irinotecan or cetuximab to alisertib.

Tumors were individually modeled in order to quantitatively assess the in vivo combinatorial effects of adding alisertib to standard of care agents. ψ is the term used in the mathematical model to define the degree of interaction. ψ values of 1 represent an additive effect, ψ > 1 represent a synergistic effect, 0 < ψ < 1 represent a less-than-additive effect, and ψ < 0 represent an antagonistic effect.