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. 2016 Jul 4;7(31):50365–50379. doi: 10.18632/oncotarget.10395

Figure 4. Inhibition of MV-release sensitizes drug-resistant pancreatic cancer cells to GEM in vitro.

Figure 4

A. Suit-2 cells and B. MPanc-96 cells were treated with either 30 μM U0126 or 1 μM GEM or both. Cell proliferation was determined after 48 h and 72 h. C. Suit-2 cells and D. MPanc-96 cells were treated as before and analyzed for cell death after 24, 48, and 72 h by flow analysis. *P < 0.05, compared to 30 μM U0126 alone, at respective time points. E. Suit-2 and Suit-2T27N cells were treated with 1 μM GEM and cell proliferation was determined after 24, 48, and 72 h. F. Cell death in Suit-2 and Suit-2T27N cells treated with 1 μM GEM was assessed with flow analysis. *P < 0.005, compared to Suit-2. Results are presented as mean ± SD. Experiments were repeated thrice, in duplicate.