Clinicopathologic features	Variable	N (% along column)	NOTCH1 transcript expression (N=35), % along row			P- value
			Up (N=14)	Basal (N=9)	Down (N=12)
Smoking	Smoker	11 (32%)	2 (18%)	6 (55%)	3 (27%)	0.026
	Non-smoker	24 (68%)	12 (50%)	3 (13%)	9 (38%)

All clinical correlation analysis were performed in SPSS and significant alterations has been presented in the table. Patient's samples showing strong and moderate staining of activated NOTCH1 was considered as having activated Notch signaling. N; Number of samples, Up; upregulation, Down; downregulation. Chi-square test was used to calculate statistical significance. Significant P-value are highlighted in bold font. P-value ≤ 0.05 was considered as threshold for significance. + denotes; marginally significant.