Table 4. Multivariate analysis and selection of NSCLC-associated molecular markers based on age- and gender-stratified subpopulations. ^#.

	Younger women N=100				Older women N=107				Younger men N=108				Older men N=182
N(Case)	39				34				42				72
N(Control)	61				73				66				110
Gene	OR	95%	CI	StdEst	OR	95%	CI	StdEst	OR	95%	CI	StdEst	OR	95%	CI	StdEst
CPEB4													5.00	2.09	11.97	0.97
DUSP6	4.25	1.69	10.65	0.66	13.64	4.23	44.06	1.29	4.13	1.74	9.79	0.63	34.21	6.67	175.39	1.46
GRB2													20.33	4.99	82.77	1.37
MCM4					6.31	1.83	21.84	0.70
MDM2	4.81	1.30	17.82	0.51					7.34	1.99	27.05	0.73
EIF2S3									0.21	0.05	0.97	−0.45
NF1					0.10	0.02	0.47	−0.55					0.10	0.02	0.46	−0.63
POLDIP2									0.28	0.09	0.86	−0.49	0.01	0.00	0.08	−1.77
RNF4					0.16	0.04	0.64	−0.54
STAT2	0.26	0.07	0.94	−0.39
WEE1	0.07	0.02	0.27	−0.96					0.26	0.09	0.76	−0.51
C statistic	0.907				0.930				0.895				0.970

^OR:odds ratio; CI: confidence interval; StdEst: standardized coefficients

^#Each multiple logistic model contains significant genes with controlling for smoking status.