Figure 2. Autophagy machinery in melanin metabolism event.

Pigmented melanosomes originated in melanocytes are transferred into neighboring keratinocytes, and the entering process is related to activation of FGF7-FGFR2 signal. UV radiation promotes FGFR2 internalization, and subsequent degradation of FGFR2 by autophagosomes/autolysosomes would ease autophagy capacity to degrade melanosomes.