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. 2016 May 14;7(31):50719–50734. doi: 10.18632/oncotarget.9368

Figure 2. Schematic representation of SETD2 with the location of functional domains and nonsynonymous mutations and variants.

Figure 2

The location of nonsynonymous mutations was obtained from ExAC (Germline variants in ~120000 alleles; January 2016) and COSMIC (somatic variants in 23,249 cases; January 2016). Intronic regions and 3′- and 5′-untranslated regions are not shown. Red, position of inactivating variants; Blue, position of missense variants. For the COSMIC data, the height of the bar is relative to the number of mutations. For the ExAC data, the height of the bars indicate 1, 2-5, 6-10, or >10 variants per triplet.