Table 2. Overview of SETD2 mutation frequencies in a selection of tumors based on the COSMIC database (Feb 2016)*.
| Tissue/tumour subtype | Percentage of samples with mutation | cases tested | |
|---|---|---|---|
| truncating | missense | ||
| Kidney | 4.19 | 3.10 | 2197 |
| ccRCC | 5.43 | 4.14 | 1473 |
| Lung | 1.26 | 1.42 | 1826 |
| Adenocarcinoma | 3.51 | 3.51 | 550 |
| Skin | 1.08 | 2.65 | 1017 |
| Liver | 0.74 | 1.55 | 1611 |
| Hepatocellular carcinoma | 0.78 | 1.12 | 893 |
| Soft tissue | 0.70 | 4.67 | 428 |
| Biliary tract | 0.66 | 0.66 | 152 |
| Adenocarcinoma | 0.67 | 0.67 | 150 |
| Endometrium | 0.63 | 3.49 | 631 |
| Endometrioid carcinoma | 0.74 | 4.08 | 539 |
| Large intestine | 0.59 | 3.05 | 1345 |
| Adenocarcinoma | 0.62 | 3.10 | 1298 |
| Breast | 0.58 | 0.94 | 1378 |
| Central nervous system | 0.47 | 0.38 | 2128 |
| Pancreas | 0.46 | 0.33 | 1521 |
| Ductal carcinoma | 0.40 | 0.57 | 1240 |
| Stomach | 0.34 | 2.04 | 587 |
| Urinary tract | 0.30 | 0.90 | 666 |
| Haematopoietic and lymphoid | 0.24 | 0.87 | 2519 |
| Acute lymphoblastic B cell leukaemia | 1.54 | 2.32 | 258 |
| Acute lymphoblastic T cell leukaemia | 0.97 | 0.97 | 207 |
| Diffuse large B cell lymphoma | 0.00 | 3.20 | 250 |
| Ovary | 0.24 | 0.59 | 843 |
| Serous carcinoma | 0.31 | 0.78 | 641 |
| Bone | 0.20 | 0.60 | 496 |
| Prostate | 0.10 | 0.88 | 1019 |
| Adenocarcinoma | 0.12 | 0.48 | 827 |
*
Tumor subtypes with a sample size less than 100 cases have been excluded.