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. 2016 May 17;7(31):50766–50780. doi: 10.18632/oncotarget.9391

Figure 1. Schematic representation of the basic structure of individual NLR domain.

Figure 1

Human NLRs were classified into five categories including NLRA, NLRB, NLRC, NLRP and NLRX. All 22 human NLRs contain a central NACHT domain and a C-terminal ligand sensing domain LRR, with the exception of NLRP10. The N-terminal domain of each NLR is specific and responsible for ascribing different biofunctions. CARD: caspase association and recruitment domain; ATD: acidic transactivation domain; FIND: function to find domain; PYD: pyrin domain; BIR: Baculoviral inhibition of apoptosis protein repeat domain; LRR: leucine-rich repeats; MT: targets NLRX1 to the mitochondria but no sequence homology with tranditional mitochondrial targeting sequence has been reported.