. 2016 Jul 6;125(1):56–65. doi: 10.1289/EHP155

Table 3.

Interaction between polymorphisms in CYP2E1 and trihalomethane (THM) exposure, dichotomized at the 75th percentile. Odds ratios (ORs) and 95% confidence intervals (CIs) among 981 cases and 2,204 controls.

Gene, SNP^a	Genotype	Cases	Controls	Total THMs (> vs. ≤ 60 μg/L)		Brominated THMs (> vs. ≤ 40 μg/L)		Chloroform (> vs. ≤ 20 μg/L)
Gene, SNP^a	Genotype	Cases	Controls	OR (95% CI)^b	Nominal p‑value^c	OR (95% CI)^b	Nominal p‑value^c	OR (95% CI)^b	Nominal p‑value^c
rs2070675	CC	682	1,496	3.5 (2.4, 5.1)	0.029	4.1 (2.7, 6.0)	0.009	0.4 (0.3, 0.6)	0.646
rs2070675	CT/TT	298	707	2.3 (1.3, 4.0)		2.1 (1.2, 3.7)		0.6 (0.4, 0.9)
rs915907	CC	710	1,566	3.3 (2.2, 4.7)	0.031	3.9 (2.7, 5.8)	0.009	0.4 (0.3, 0.5)	0.392
rs915907	AC/AA	252	618	2.6 (1.4, 5.0)		2.3 (1.2, 4.3)		0.8 (0.5, 1.2)
rs8192775	GG	850	1,884	3.1 (2.2, 4.4)	0.103	3.7 (2.6, 5.3)	0.021	0.5 (0.4, 0.6)	0.383
rs8192775	AG/AA	131	320	2.7 (1.1, 6.5)		1.7 (0.8, 3.9)		0.5 (0.2, 1.0)
rs743535	GG	838	1,823	3.0 (2.1, 4.3)	0.056	3.7 (2.6, 5.3)	0.019	0.5 (0.3, 0.6)	0.066
rs743535	AG/AA	142	381	3.4 (1.5, 7.8)		2.0 (0.9, 4.3)		0.5 (0.3, 0.9)
Notes: SNP, single nucleotide polymorphism. ^aResults for all SNPs are reported in Table S2. ^bAdjusted for sex, age, geographical area and education. ^cLikelihood-ratio test for the joint effect of the SNP and interaction term. Critical p-value with Bonferroni corrections, p < 0.003.