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. 2016 Jul 22;125(1):82–88. doi: 10.1289/EHP211

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Clonal expansion of the mutations characterized in each somatic tissue and in caudal sperm. The proportion of mutations that underwent clonal expansion is consistently higher in animals exposed to benzo[a]pyrene (BaP) in utero, illustrating the potential for increased mosaicism. As in somatic tissues, the proportion of clonally expanded mutations is higher in BaP-exposed sperm, highlighting the potential for increased germline mosaicism. Compared with exposure in adults (data from Beal et al. 2015 and O’Brien et al. 2016b), in utero exposure results in a higher degree of clonal expansion. Plaques were collected from the 20 mg/kg/day dose group for cadual sperm because of decreased sperm concentration at 40 mg/kg/day. Each circle within a group corresponds to a scored independent mutation, and the area of each circle represents the number of times that mutation was observed per animal. INS, insertion; DEL, deletion.