Table 3.

Top 10 significant CpGs within oxidative stress genes extracted from the epigenome-wide meta-analysis of the association between prenatal NO₂ exposure and newborn cord blood DNA methylation (n = 1,508 newborns from MeDALL, Generation R, CHS, and MoBa cohorts).

Chr	Position (build 37)	CpG	Mapped gene	Gene group	Coef	SE	p-Value	Direction
11	34460856	cg03728580	CATFDR	Body	0.003	0.001	0.00001	++++
11	34461028	cg17034036	CATFDR	Body	0.002	0.001	0.0001	++++
2	1482597	cg01385533	TPOFDR	Body	–0.003	0.001	0.0004	–?––
1	226023590	cg05935800	EPHX1	Body	–0.002	0.001	0.002	––––
20	33539306	cg13607138	GSS	Body	–0.003	0.001	0.003	––?–
8	107642385	cg17526936	OXR1	Body	–0.002	0.001	0.004	––?–
2	1544120	cg19407717	TPO	Body	–0.002	0.001	0.004	––––
2	1479523	cg13703866	TPO	Body	–0.001	0.000	0.005	––––
11	34460336	cg07768201	CAT	TSS200	0.003	0.001	0.006	++++
1	226012507	cg03337430	EPHX1	TSS1500;5’UTR	0.001	0.000	0.006	+–++
Shown are the top 10 CpGs ordered by p-value. Three CpGs were statistically significant using genome-wide significance threshold (FDR p < 0.05). Results presented per 10 μg/m3 increase in prenatal NO2 exposure. Column heads: Chr: chromosome; Position: chromosomal position based on NCBI human reference genome assembly Build 37. Mapped Gene: UCSC annotated gene; Gene group: UCSC gene region feature category; Coef: regression coefficient; SE: standard error for regression coefficient; Direction: direction of effect across cohorts included in the statistical model (MeDALL, Generation R, CHS, and MoBa): NO2 exposure during pregnancy associated with increased (+) or decreased (–) methylation, or missing (?) result.