Fig 4. Enhanced Th1 and reduced Treg and Th17 responses in IL-37 transgenic mice during mycobacterial infection.

Kinetics of Treg (A), Th1 (B) and Th17 (C) cells in the spleens of WT and IL-37-Tg mice infected with BCG. The frequencies of CD4⁺CD25⁺FoxP3⁺ (A), CD4⁺IFNγ⁺ (B) and CD4⁺IL-17⁺ (C) cells among gated lymphocytes were determined at indicated times p.i. Results are the mean±SEM and are pooled from two independent experiments; n = 4 or 5 for each time point; two way ANOVA with Bonferroni’s post test. **, p<0.01.