. 2017 Jan 11;12(1):e0169519. doi: 10.1371/journal.pone.0169519

Table 2. MicroCT measured parameters of diaphyseal cortical bone at distances of 25%, 37%, 50% and 75% of the tibial length from its proximal end and metaphyseal cancellous bone, in mice subjected to axial compressive loading for 2 weeks under 216 daily load cycles with and without rest insertion.

Parameters		216 Cycles without Rest		216 Cycles with 10 s Rest
Parameters		Control	Loaded	Control	Loaded
Diaphyseal Cortical Bone
Ct.Ar (mm²)	25% ^A	0.878±0.051	0.981±0.033	0.866±0.038	0.962±0.024
	37% ^A	0.797±0.035	0.932±0.038	0.791±0.041	0.907±0.033
	50% ^A	0.632±0.028	0.716±0.032	0.635±0.042	0.707±0.034
	75% ^A	0.574±0.032	0.582±0.033	0.560±0.023	0.577±0.028
Tt.Ar (mm²)	25% ^A	3.584±0.218	3.904±0.273	3.557±0.354	3.775±0.248
	37% ^A	2.994±0.181	3.227±0.196	3.076±0.169	3.213±0.195
	50% ^A	1.508±0.099	1.609±0.091	1.532±0.120	1.628±0.101
	75%	1.153±0.069	1.199±0.128	1.144±0.077	1.172±0.067
Ma.Ar (mm²)	25% ^A	2.706±0.185	2.923±0.259	2.691±0.319	2.813±0.230
	37%	2.197±0.157	2.296±0.169	2.285±0.186	2.306±0.176
	50%	0.877±0.075	0.893±0.070	0.897±0.081	0.921±0.086
	75%	0.580±0.051	0.617±0.138	0.584±0.061	0.595±0.050
Ct.Th (mm)	25% ^A	0.183±0.005	0.201±0.007	0.180±0.007	0.196±0.006
	37% ^A	0.190±0.004	0.217±0.005	0.190±0.006	0.213±0.005
	50% ^A	0.218±0.006	0.244±0.008	0.216±0.007	0.240±0.010
	75% ^A	0.235±0.009	0.239±0.009	0.231±0.005	0.236±0.010
I_max (mm⁴)	25% ^A	0.281±0.034	0.315±0.035	0.282±0.019	0.310±0.026
	37% ^A	0.217±0.021	0.257±0.028	0.218±0.024	0.249±0.026
	50% ^A^,^C	0.074±0.009	0.092±0.009	0.077±0.011	0.090±0.011
	75%	0.051±0.005	0.051±0.005	0.050±0.005	0.051±0.005
I_min (mm⁴)	25% ^A	0.120±0.016	0.154±0.020	0.120±0.011	0.150±0.013
	37% ^A	0.078±0.008	0.101±0.009	0.079±0.009	0.098±0.008
	50% ^A	0.062±0.006	0.069±0.007	0.063±0.009	0.069±0.008
	75% ^A	0.040±0.004	0.041±0.005	0.040±0.004	0.041±0.004
Ct.TMD (mg HA/cm³)	25%	1033±6	1033±8	1035±7	1033±9
	37% ^A	1050±9	1043±8	1053±6	1042±8
	50%	1113±9	1118±8	1112±7	1114±7
	75%	1101±9	1103±8	1098±6	1100±10
Metaphyseal Cancellous Bone
TV (mm³)		1.83±0.14	1.87±0.15	1.86±0.11	1.82±0.27
Tb.N (1/mm)		3.6±0.2	3.6±0.3	3.7±0.2	3.5±0.3
Tb.Sp (μm)		274±20	273±25	264±14	280±30
Cn.TMD (mg HA/cm³) ^A		759±9	786±9	762±18	778±13

Data are given as mean ± SD.

^A main effect of loading;

^B main effect of rest insertion;

^C interactive effect of loading and rest insertion (within-subject factor: control vs. loaded, between-subject factor: 10 s rest vs. no rest).

Bold denotes a difference between loaded and control tibiae within each loading group when an interaction is present.