Table 1. Euclidean Distance between the estimated stain matrix and the ground truth.

The median of the Euclidean distances for each method is shown in the last two columns. Last row shows the median of the Euclidean distances for all methods to highlight the significance of the best achieved median values.

	Colon Dataset		Breast Dataset		Lung Dataset		Median
	H	E	H	E	H	E	H	E
Proposed	0.0623	0.0871	0.0537	0.0585	0.1377	0.0779	0.0592	0.085
Macenko et al. [11]	0.0774	0.2002	0.1202	0.0488	0.0936	0.9949	0.0971	0.4146
Ruifrok and Johnston [10]	0.1980	0.2017	0.2201	0.3150	0.1826	0.1917	0.2002	0.2361
BCD [13]	0.3789	0.3282	0.4027	0.3606	0.3897	0.3655	0.3905	0.3514
ICA [12]	0.2795	0.3349	0.5219	0.5607	0.4081	1.2451	0.4032	0.7136
Median	0.198	0.2017	0.2201	0.315	0.1826	0.3655	—	—