Table 3.

Categorized levels of galectin-3 and risk of mortality (all-cause, CV) or event (new-onset HF, new-onset AF and CV event)

Model	New-onset HF (95% CI)	P	Cardiovascular mortality (95% CI)	P	All-cause mortality (95% CI)	P	New-onset AF (95% CI)	P	Cardiovascular event (95% CI)	P
Unadjusted
Low-low	1.00		1.00		1.00		1.00		1.00
High-low	1.80 [0.98–3.32]	0.06	1.08 [0.39–3.02]	0.88	1.45 [1.08–1.95]	0.01	1.41 [0.86–2.33]	0.18	1.23 [0.87–1.73]	0.24
Low-high	0.93 [0.35–2.51]	0.89	1.94 [0.67–5.66]	0.22	2.35 [1.69–3.28]	<0.001	1.38 [0.70–2.74]	0.35	1.32 [0.83–2.09]	0.24
High-high	4.71 [2.94–7.56]	<0.001	6.38 [3.28–12.43]	<0.001	3.12 [2.46–3.96]	<0.001	2.17 [1.39–3.38]	0.001	2.06 [1.54–2.77]	<0.001
Age and gender adjusted
Low-low	1.00		1.00		1.00		1.00		1.00
High-low	1.01 [0.54–1.92]	0.97	0.50 [0.17–1.51]	0.22	0.91 [0.67–1.23]	0.54	0.91 [0.55–1.50]	0.72	0.80 [0.56–1.14]	0.21
Low-high	0.55 [0.21–1.48]	0.24	0.94 [0.32–2.80]	0.91	1.59 [1.14–2.22]	0.007	0.93 [0.46–1.90]	0.85	0.94 [0.59–1.50]	0.79
High-high	1.98 [1.16–3.35]	0.01	2.19 [1.08–4.46]	0.03	1.42 [1.10–1.82]	0.007	1.10 [0.70–1.72]	0.69	1.10 [0.81–1.50]	0.55
Multivariable full adjustment
Low-low	1.00		1.00		1.00		1.00		1.00
High-low	1.15 [0.59–2.27]	0.68	0.27 [0.11–0.65]	0.004	0.93 [0.68–1.29]	0.68	1.00 [0.58–1.71]	0.99	0.79 [0.54–1.14]	0.20
Low-high	0.57 [0.21–1.57]	0.28	0.83 [0.23–2.98]	0.77	1.51 [1.04–2.19]	0.03	1.01 [0.49–2.09]	0.98	0.87 [0.53–1.41]	0.57
High-high	1.94 [1.08–3.50]	0.03	1.47 [0.70–3.08]	0.31	1.36 [1.02–1.80]	0.03	1.09 [0.67–1.79]	0.72	0.93 [0.66–1.29]	0.65

^*Adjusted for age, sex, smoking, diabetes mellitus type 2, history of myocardial infarction or stroke, hypertension, hypercholesterolemia, waist-hip-ratio, BMI, systolic blood pressure, diastolic blood pressure, triglycerides, glucose, estimated GFR, urinary albumin excretion, CRP, NT-proBNP.