Fig. 9.

Cerebellum connectivity analysis. Seed location placed in cerebellum crus I. A. Significant clusters that have negative connectivity to seed region in patients. Three different views are shown. Regions of interest (ROI) are labeled 1–3. ROI1 included parts of the central opercular cortex, postcentral gyrus, precentral gyrus, parietal operculum, supramarginal gyrus, insular cortex, Heschl's gyrus, planum tempolare, and planum polare. ROI2 included parts of parietal and central operculum cortex, postcentral gyrus, precentral gyrus, insular cortex, planum tempolare, Heschl's gyrus, and supramarginal gyrus. ROI3 included parts of the supplementary motor cortex and precentral gyrus. B. Scatter plots of significant correlations with clinical variable red blood cell units. The linear trend line of ROI1 had p < 0.001 and the linear trend line of ROI2 had p < 0.005. Both relationships showed reduced magnitude of negative connectivity related to increased red blood cell units. C. Box plot showing differences of negative connectivity values between patients and controls. Patients all showed significant negative connectivity in each region compared to controls. The * shows significance where p < 0.05, and the ** shows significance where p < 0.005.