Table 4.

Effect estimates for maternally-mediated genetic effects of previous breast cancer genome-wide association study risk variants on the risk of young-onset breast cancer

Rank	SNPa	Gene	RR (95% CI)	p-value
1	rs9790517	TET2	0.78 (0.66, 0.94)	0.007
2	rs10995190	ZNF365	0.75 (0.61, 0.93)	0.008
3	rs9693444	8p12	0.81 (0.70, 0.93)	0.008
4	rs2236007	PAX9	1.21 (1.01, 1.45)	0.03
5	rs2016394	DLX2	0.85 (0.73, 0.99)	0.04
6	rs2588809	RAD51B	0.84 (0.69, 1.02)	0.07
7	rs2943559	HNF4G	0.80 (0.62, 1.04)	0.09
8	rs6504950	STXBP4	1.15 (0.97, 1.35)	0.10
9	rs6828523	ADAM29	1.19 (0.94, 1.49)	0.15
10	rs2981579	FGFR2	0.90 (0.78, 1.04)	0.15
11	rs10771399	12p11.22	0.84 (0.66, 1.08)	0.17
12	rs720475	ARHGEF5	0.89 (0.75, 1.05)	0.18
13	rs8170	BIBAM1	0.87 (0.71, 1.07)	0.18
14	rs2046210	ESR1	1.10 (0.95, 1.28)	0.20
15	rs12422552	12p13.1	0.90 (0.76, 1.06)	0.21
16	rs4245739	MDM4	1.11 (0.94, 1.32)	0.22
17	rs1045485	CASP8	0.87 (0.70, 1.09)	0.23
18	rs7904519	TCF7L2	0.92 (0.79, 1.06)	0.25
19	rs3817198	LSP1	0.91 (0.77, 1.07)	0.26
20	rs865686	RPL31P43	1.09 (0.93, 1.27)	0.28
21	rs13281615	8q24.21	1.09 (0.93, 1.27)	0.28
22	rs3903072	11q13.1	1.09 (0.93, 1.27)	0.29
23	rs11242675	FOXQ1	1.09 (0.93, 1.27)	0.30
24	rs10759243	9q31.2	0.91 (0.76, 1.09)	0.31
25	rs11820646	11q24.3	0.93 (0.80, 1.07)	0.31
26	rs12662670	ESR1	0.88 (0.67, 1.15)	0.34
27	rs2380205	GDI2	0.93 (0.79, 1.08)	0.34
28	rs13387042	TNP1	1.07 (0.92, 1.25)	0.36
29	rs999737	RAD51B	0.93 (0.78, 1.10)	0.38
30	rs4849887	2q14.2	0.92 (0.72, 1.16)	0.47
31	rs17356907	12q22	0.94 (0.80, 1.12)	0.49
32	rs13329835	CDYL2	1.06 (0.88, 1.28)	0.52
33	rs6762644	ITPR1	0.95 (0.82, 1.11)	0.53
34	rs204247	RANBP9	0.95 (0.82, 1.11)	0.54
35	rs1292011	12q24.21	0.95 (0.81, 1.12)	0.55
36	rs616488	PEX14	0.95 (0.82, 1.11)	0.55
37	rs4973768	SLC4A7	0.95 (0.82, 1.11)	0.55
38	rs10069690	TERT	0.95 (0.80, 1.13)	0.56
39	rs11814448	10p12.31	0.90 (0.57, 1.41)	0.64
40	rs10941679	MRPS30	0.96 (0.80, 1.15)	0.65
41	rs16857609	DIRC3	0.96 (0.81, 1.14)	0.66
42	rs1550623	CDCA7	0.96 (0.78, 1.18)	0.67
43	rs2736108	TERT	0.96 (0.79, 1.17)	0.67
44	rs6678914	LGR6	1.03 (0.88, 1.21)	0.68
45	rs527616	18q11.2	1.04 (0.87, 1.25)	0.68
46	rs12493607	TGFBR2	0.97 (0.83, 1.13)	0.71
47	rs704010	ZMIZ1	0.97 (0.83, 1.14)	0.71
48	rs78540526	CCND1	1.05 (0.78, 1.42)	0.73
49	rs3803662	TOX3	0.97 (0.82, 1.15)	0.74
50	rs889312	MAP3K1	0.97 (0.83, 1.15)	0.75
51	rs11075995	FTO	0.97 (0.82, 1.15)	0.76
52	rs75915166	FGF3	1.05 (0.77, 1.42)	0.76
53	rs1436904	CHST9	1.02 (0.87, 1.20)	0.77
54	rs1353747	PDE4D	0.97 (0.75, 1.24)	0.79
55	rs1011970	CDKN2B	0.97 (0.79, 1.19)	0.80
56	rs11199914	10q26.12	0.98 (0.83, 1.16)	0.81
57	rs2363956	ANKLE1	0.98 (0.85, 1.14)	0.81
58	rs4808801	ELL	0.98 (0.84, 1.15)	0.82
59	rs941764	CCDC88C	0.98 (0.84, 1.16)	0.83
60	rs1432679	EBF1	1.01 (0.87, 1.17)	0.89
61	rs11249433	EMBP1	0.99 (0.85, 1.15)	0.89
62	rs12710696	LINC01376	1.01 (0.86, 1.19)	0.90
63	rs17817449	FTO	0.99 (0.85, 1.16)	0.90
64	rs11552449	AP4B1	0.99 (0.81, 1.21)	0.92
65	rs7726159	TERT	0.99 (0.82, 1.20)	0.92
66	rs554219	CCND1	1.01 (0.82, 1.25)	0.92
67	rs10472076	RPL5P15	1.01 (0.87, 1.17)	0.93
68	rs132390	EMID1	1.02 (0.62, 1.69)	0.93
69	rs11780156	8q24.21	0.99 (0.81, 1.22)	0.95
70	rs2823093	CYRR1	1.00 (0.85, 1.17)	0.95
71	rs6001930	MKL1	1.01 (0.79, 1.29)	0.95
72	rs7072776	MLLT10	1.00 (0.85, 1.16)	0.96
73	rs3760982	KCNN4	1.00 (0.86, 1.16)	1.00

Abbreviations: CI= Confidence Interval; RR = risk ratio

^aImputed SNPs are italicized